(19) United States

US 20 1 0020943 5A1
(19) United States
(12) Patent Application Publication (10) Pub. N0.2 US 2010/0209435 A1
Boyle et al.
(54)
(75)
(43) Pub. Date:
HUMAN ANTI-OPGL NEUTRALIZING
ANTIBODIES As SELECTIVE OPGL
PATHWAY INHIBITORS
_
Inventors.
. .
-
William J. Boyle, Mahbu, CA
(63)
(
60
(US); Eugene Medlock, Westlake,
CA (U S); John K. Sullivan,
NeWbury Park, CA (US); Robin L.
Related U.S. Application Data
Continuation of application No. 10/408,901, ?led on
Apr. 7, 2003, noW Pat. NO. 7,718,776.
Provisional a
5 2002
’
pp
lication No. 60/370,407, ?led onA r.
p
'
Publication Classi?cation
(51) Int Cl
Elliott, NeWbury Park, CA (U S);
'
gfg?‘lchun
Frank Martin, Huang’
NeWburyFremont’
Park, CA
'
C07H 21/04
(2006.01)
C12N 15/63
(2006.01)
C12N 5/10
Correspondence Address:
BOEHNEN HULBERT & BERG-
églsc'ivGAgl?lzolzg‘?s’ 32M) FLOOR
’
( )
Aug. 19, 2010
(52)
2006.01
C121; 21/02
E200601;
A611; 19/10
(200601)
A61P 19/08
(2006.01)
U.S. Cl. .............. .. 424/1581; 530/3892; 536/2353;
435/320.1; 435/358; 435/69.6
(73) Assignees:
AMGEN INC., Thousand Oaks,
CA (Us); MEDAREX’ INC"
Pnnceton, NJ (Us)
(57)
ABSTRACT
Monoclonal antibodies and hybridomas producing them that
interact With osteoprotegerin ligand (OPGL) are provided.
(21)
Appl. No.1
12/705,962
(22)
Filed;
Feb, 15, 2010
pharmaceutically effective amount of antibodies to OPGL are
also provided. Methods of detecting the amount of OPGL in
a sample using antibodies to OPGL are further provided.
Methods of treating osteopenic disorders by administering a
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