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Lieky & liekové skupiny
Jak zvýšit analgetickou účinnost paracetamolu?
prof. MUDr. Miloslav Kršiak, DrSc.
Ústav farmakologie 3. lékařské fakulty Univerzity Karlovy v Praze
Obvyklá jednotlivá dávka samotného paracetamolu (500 mg per os) představuje u osob nad 50 kg hmotnosti podprahovou dávku
(< 10 mg/kg). U osob s hmotností nad 60 kg je proto doporučována dávka 1 g paracetamolu. Pokud samotný paracetamol ani v dávce
1 g per os netlumí bolest dostatečně, je třeba volit jiné analgetikum, nebo použít kombinaci paracetamolu s dalšími látkami, např.
s opioidy, nesteroidními antirevmatiky (je-li to možné), kofeinem nebo jinými. Někdy pomůže urychlení vstřebání paracetamolu z jeho
rozpustných lékových forem.
Klíčová slova: paracetamol, bolest, dávkování, plazmatické koncentrace, analgetické kombinace.
How to increase analgesic efficacy of paracetamol?
A usual single dose of paracetamol (500 mg per os) represents a subthreshold dose (< 10 mg/kg) in patiens with body weight over 50 kg
(i. e. in most adults). A single dose of 1 g of paracetamol is therefore recommended in patients over 60 kg in weight. If paracetamol does
not inhibit pain sufficiently even at this dose (1 g), then another analgesic is to be selected or combinations of paracetamol with other
drugs can be used, e. g. those with opioids, NSAIDs (if possible), caffeine or others. Sometimes it may be helpful to speed up absorption
of paracetamol by using effervescent or well soluble paracetamol preparations per os.
Key words: paracetamol (acetaminophen), pain, dosage, plasma concentrations, analgesic combinations.
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Článok je prevzatý
z Interní Med. 2011; 13(3): 140–142.
prof. MUDr. Miloslav Kršiak, DrSc.
Ústav farmakologie 3. LF UK
Ruská 87, 100 00 Praha 10
[email protected]
Tlačová správa
Fond GSK – jeseň života môže byť plná farieb
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