Produkce modelů laboratorních zvířat společnosti TACONIC [PDF, 0
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Produkce modelů laboratorních zvířat společnosti TACONIC [PDF, 0
Produkce modelů laboratorních zvířat společnosti TACONIC Model 129S6 Abb [B6.SJL-Ptprca] (H2-Ab1) Abb [C57BL/6] (H2-Ab1) Ahr Knockout Mouse ApoB100 Apoe (ApoE) APOE2 APOE3 APOE4 APPSWE [129S6] APPSWE [B6;SJL] Č. modelu 129SVE 4026 ABBN12 9166 1004 APOE 1547 1548 1549 2789 1349 APPSWE-Tau 2469 APPSWE-Tau control β-actin-luc LPTA® β-actin-luc LPTA® B10.A B2m [C57BL/6] (β2m) B6 Albino B6 Albino A++ B6.SJL B6129F1 B6C3F1 B6D2F1 B6SJLF1 BALB/c BALB/c J Bom BALB/c nude BALB/c A Bom Bcrp Black 6 Black 6 J Bom Black 6 nude Black Swiss Brca1-Associated Breast Cancer Mouse C.B-17 C.B-17 scid C3H CamKII-cre Car Knockout Mouse Ccr2 Ccr5 CETP CETP-ApoB100 CIEA BRG mouse CIEA NOG mouse® COX-1 COX-2 Custom Hybrids Cre Deleter CreERT2 CRE-Luc* GPCR Reporter Mouse, Line 11 CRE-Luc* GPCR Reporter Mouse, Line 64 CRE-Luc* GPCR Reporter Mouse, Line 187 Cyp1a1/1a2 Knockout Mouse Cyp2c Knockout Mouse Cyp2d Knockout Mouse Cyp3a (7-gene) Knockout Mouse Cyp3a (8-gene) Knockout Mouse Cyp3a-Cyp2d-Cyp2c Knockout Mouse Dark Agouti DBA/1 DBA/2 Diabetic Diet Induced Obese Fcer1g [C57BL/6] (FcRγ) Fcgr2b [C57BL/6] (FcγIII) Fischer 3273 10498 10500 4011 B2MN12 11971 11227 4007 B6129 B6C3F1 B6D2F1 B6SJL BALB BALJBO BALBNU BALBOM 2767 B6 B6JBOM B6NU BLKSW 11510 CB17 CB17SC C3H ART0009 9103 3736 3737 3715 3716 11503 NOG 2180 2181 CUSHYB 6467 10471 11515 11518 11520 ITI0122 9177 9178 8841 9011 ITI0117 DA DBA1BO DBA2 DB DIO 583 580 F344 Nomenklatura 129S6/SvEvTac B6.SJL(129)-Ptprca H2-Ab1tm1Gru/BoyAiTac B6.129-H2-Ab1tm1Gru N12 C57BL/6-Ahrtm1.2Arte B6.SJL-Tg(APOB)1102Sgy N20+? B6.129P2-Apoetm1Unc N11 B6.129P2-Apoetm1(APOE*2)Mae N9 B6.129P2-Apoetm2(APOE*3)Mae N8 B6.129P2-Apoetm3(APOE*4)Mae N8 129S6.Cg-Tg(APPSWE)2576Kha N20+? B6;SJL-Tg(APPSWE)2576Kha STOCK Tg(APPSWE)2576Kha Tg(Prnp-MAPT*P301L)JNPL3Hlmc STOCK FVB/NTac-Tg(Actb-luc)46Xen B6;FVB-Tyrc-2J Tg(Actb-luc)46Xen B10.A-H2aH2-T18a/SgSnAiTac B6.129-B2mtm1Jae N12 C57BL/6NTac-Tyrtm1Arte C57BL/6NTac-Atm1.1ArteTyrtm1Arte B6.SJL-Ptprca/BoyAiTac B6129S6F1/Tac B6C3F1/Tac B6D2F1/Tac B6SJLF1/Tac BALB/cAnNTac BALB/cJBomTac C.Cg-Foxn1nu/AnNTac BALB/cABomTac FVB.129P2-Abcg2tm1Ahs N7 C57BL/6NTac C57BL/6JBomTac B6NTac.Cg-Foxn1nu/Tac NTac:NIHBS STOCK Trp53tm1Brn Brca1tm1Brn Tg(KRT14-cre)8Brn C.B-Igh-1b/IcrTac C.B-Igh-1b Prkdcscid/IcrTac C3H/HeNTac C57BL/6NTac-Tg(Camk2a-cre)159Kln/Arte C57BL/6-Nr1i3tm1.1Arte B6.129P2-Ccr2tm1Mae B6.129P2-Ccr5tm1Kuz B6.SJL-Tg(APOA-CETP)1Dsg N11 B6.SJL-Tg(APOA-CETP)1Dsg Tg(APOB)1102Sgy N10 C.Cg-Rag2tm1Fwa Il2rgtm1Sug/JicTac NOD.Cg-Prkdcscid Il2rgtm1Sug/JicTac B6;129P2-Ptgs1tm1Unc B6;129P2-Ptgs2tm1Unc C57BL/6NTac-Gt(ROSA)26Sortm16(cre)Arte C57BL/6NTac-Gt(ROSA)26Sortm9(cre/ESR1)Arte FVB/NTac-Tg(CRE/Tk-luc)11Hgp FVB/NTac-Tg(CRE/Tk-luc)64Hgp FVB/NTac-Tg(CRE/Tk-luc)187Hgp C57BL/6-Cyp2ctm1104Arte C57BL/6-Del(15Cyp2d22-Cyp2d26)1Arte C57BL/6NTac-Del(5Cyp3a57-Cyp3a59)1Arte FVB.129P2-Cyp3a13tm1Ahs Del(5Cyp3a57-Cyp3a59)1Ahs DA/MolTac DBA/1JBomTac DBA/2NTac BKS.Cg-LeprdbDock7m/BomTac C57BL/6NTac B6.129P2-Fcer1gtm1Rav N12 B6.129S4-Fcgr2btm1Ttk N12 F344/NTac USA • • • • • • • • • • • EU • • strana 5 - • - • • • • • • • • • • • • • 13 13 13 13 5 5 10 6 6 11 6 14 7 7 10 6 14 • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • 1 Produkce modelů laboratorních zvířat společnosti TACONIC Model Floxed Ink4a/Arf Mouse Floxed p53 Mouse Flp Deleter FVB Gfap-luc LPTA® Goto-Kakizaki Gsk3a (Glycogene Synthase Kinase 3 Alfa) KinaseSwitch Mouse Gsk3b (Glycogene Synthase Kinase 3 Beta) KinaseSwitch Mouse HLA-A1 HLA-A11 HLA-A2.1 HLA-A24 HLA-B44 Č. modelu 11511 11512 7089 FVB 10501 GK Nomenklatura B6.129P2-Cdkn2atm2Brn/A B6.129P2-Trp53tm1Brn/A C57BL/6NTac-Tg(CAG-Flpe)2Arte N5 FVB/NTac FVB/N-Tg(Gfap-luc)53Xen GK/MolTac[cc] ART0069 C57BL/6-Gsk3atm1Arte • - ART0059 tm1Arte C57BL/6-Gsk3b • - 9662 9660 9659 9663 9664 • • • • • - HLA-B7 9661 • - HRN™ HRN™ nude Humanized AHR Mouse Humanized CAR Mouse Humanized CYP1A1/1A2 Mouse Humanized CYP2D6 Mouse Humanized CYP3A4/3A7 Mouse 7353 9066 9165 9101 ITI0111 11584 8842 CB6F1-Tg(HLA-A*0101/H2-Kb)A1.01 CB6F1-Tg(HLA-A*1101/H2-Kb)A11.01 CB6F1-Tg(HLA-A*0201/H2-Kb)A*0201 CB6F1-Tg(HLA-A*2402/H2-Kb)A24.01 CB6F1-Tg(HLA-B*4002/H2-Kb)B44.01 CB6F1-B2mtm1Unc Tg(B2M)55Hpl Tg(HLA-B*0702/H2-Kb)B7.xx B6.Cg-Portm1Wolf Tg(Alb-cre)21Mgn N7 CrTac:NCr-Portm1Wolf Foxn1nu Tg(Alb-cre)21Mgn C57BL/6-Ahrtm1.1(AHR)Arte C57BL/6-Nr1i3tm1(NR1I3)Arte • • • • • • • - Humanized Gut CYP3A4 Mouse 9047 • - • - • - • - • - • - • - • - • • • - • - ITI0134 • - ITI0100 • - ITI0123 11996 ICR ICRSC 9189 9012 11509 1147 DR DS LEWIS LONGEV MDR1A 1487 3998 1486 6621 NCRNU 10499 NIHRNU NMRI NMRINU • • • • • • • • • • • • • • • • • • • • 9 12 16 16 15 16 10 19 9 11 Humanized Liver & Gut CYP3A4 Mouse 9049 Humanized Liver CYP2C9 Mouse 11746 Humanized Liver CYP3A4 Mouse 9048 Humanized MRP2 Mouse 9179 Humanized OATP1B1 Mouse 10708 Humanized OATP1B1/ 1B3 Mouse 11594 Humanized OATP1B3 Mouse 10725 Humanized PXR Mouse Humanized PXR-CAR Mouse Humanized PXR-CAR-AHR Mouse 9104 8223 ITI0082 Humanized PXR-CAR-CYP3A4/3A7 Mouse 11585 Humanized PXR-CAR-CYP3A4/3A7CYP2D6 Mouse Humanized PXR-CAR-CYP3A4/3A7CYP2D6-CYP2C9 Mouse Humanized PXR-CAR-PPARα Mouse Humanized UGT1A1*1 Mouse ICR ICR scid Inducible Type II Diabetes Mouse Inducible Type II Diabetes Rat Invasive Lobular Breast Cancer Model Jh Levin Levin Lewis Long Evans Mdr1a Mdr1a/b Mdr1a/b-Bcrp Mrp1 Mrp2 NCr nude NFκB-RE-luc LPTA® NIH nude NMRI NMRI nude C57BL/6-Is(15CYP2D6;Del15Cyp2d22-Cyp2d26)3Arte C57BL/6-Del(5Cyp3a57-Cyp3a59)1Artetm1(CYP3A4-CYP3A7)Arte FVB.129P2-Cyp3a13tm1Ahs Del(5Cyp3a57-Cyp3a59)1Ahs Tg(Vil1-CYP3A4)1Ahs FVB.129P2-Cyp3a13tm1Ahs Del(5Cyp3a57-Cyp3a59)1Ahs Tg(Vil1-CYP3A4)1Ahs Tg(APOE-CYP3A4)A1Ahs FVB.129P2-Cyp3a13tm1Ahs Del(5Cyp3a57-Cyp3a59)1Ahs Tg(APOE-CYP3A4)A1Ahs C57BL/6-Abcc2tm1(ABCC2)Arte FVB.129P2-Del(Slco1b2-Slco1a5)1Ahs Tg(APOE-SLCO1B1)1Ahs FVB.129P2-Del(Slco1b2-Slco1a5)1Ahs Tg(APOE-SLCO1B1)1Ahs Tg(APOE-SLCO1B3)1Ahs FVB.129P2-Del(Slco1b2-Slco1a5)1Ahs Tg(APOESLCO1B3)1Ahs C57BL/6-Nr1i2tm1(NR1I2)Arte C57BL/6-Nr1i2tm1(NR1I2)Arte Nr1i3tm1(NR1I3)Arte C57BL/6-Nr1i3tm1(NR1I3)Arte Is(5CYP3A4-CYP3A7; Del5Cyp3a57-Cyp3a59)2Arte Nr1i2tm1(NR1I2)Arte B6.Cg-UgttmRhtu Tg(UGT1A1*28)1Rhtu IcrTac:ICR IcrTac:ICR-Prkdcscid C57BL/6NTac-Gt(ROSA)26Sortm31(H1/tet0-RNAi:Insr)Arte NTac:SD-Tg(H1/tetO-RNAi:Insr)29Bdr FVB.Cg-Cdh1tm1Jjon Trp53tm1Brn Tg(KRT14-cre)8Brn/A STOCK Igh-Jtm1Dhu N?+N2 TacLevin:CD(SD)DIO TacLevin:CD(SD)DR LEW/MolTac SimTac:LE FVB.129P2-Abcb1atm1Bor N7 FVB.129P2-Abcb1atm1BorAbcb1btm1Bor N12 FVB.129P2-Abcb1atm1Bor Abcb1btm1Bor Abcg2tm1Ahs N7 FVB.129P2-Abcc1atm1Bor N12 FVB.129P2-Abcc2atm1Ahs N7 CrTac:Ncr-Foxn1nu BALB/c-Tg(Rela-luc)31Xen NTac:NIH-Whn BomTac:NMRI BomTac:NMRI-Foxn1nu USA • • • • • • EU • • strana 7 - 2 Produkce modelů laboratorních zvířat společnosti TACONIC Model NOD NOD scid Ntrk1 (Neurotrophic Tyrosine Kinase Receptor Type 1) KinaseSwitch Mouse Ntrk2 (Neurotrophic Tyrosine Kinase Receptor Type 2) KinaseSwitch Mouse Oatp1a/1b Cluster Knockout Mouse Oct1/2 Pfp/Rag2 Pirc Pparα PXR Pxr Knockout Mouse Pxr-Car Knockout Mouse Pxr-Car-Ahr Knockout Mouse Pxr-Car-Pparα Knockout Mouse Rag2 Rag2 [129S6] Rag2 [BALB/c] Rag2 [C57BL/6] Rag2/OT-I Rag2/OT-II rasH2 scid-beige SJL Spontaneously Hypertensive Sprague Dawley® Stat1 Swiss nude Swiss Webster Tau Tau TNF-α TSG-p53® [C57BL/6 N12] TSG-p53® [C57BL/6 N4] TSG-p53® [C57BL/6 N5] v-Ha-ras Wistar Hannover GALAS™ Wistar Kyoto Č. modelu NOD NODSC Nomenklatura NOD/MrkTac NOD/MrkBomTac-Prkdcscid USA • • EU • strana 7 12 ART0066 tm1Arte C57BL/6-Ntrk1 • - ART0067 C57BL/6-Ntrk2tm1Arte • - 10707 6622 1177 PIRC 1640 1414 9100 8222 11583 ITI0141 461 RAG2 601 RAGN12 2334 1896 1178 CBSCBG SJL SHR SD 2045 NSWNU SW 2508 1638 1006 P53N12 P53N4 P53N5 TGAC WH WKY FVB.129P2-Del(Slco1b2-Slco1a5)1Ahs FVB.129P2-Slc22a1tm1Ahs Slc22a2tm1Ahs N7 B6.129S6-Rag2tm1Fwa Prf1tm1Clrk N12 F344/NTac-Apcam1137 B6.129S4-Pparatm1Gonz N12 B6.129-Nr1i2tm1Sakl N10 C57BL/6-Nr1i2tm3Arte C57BL/6-Nr1i2tm3Arte Nr1i3tm1.1Arte C57BL/6-Nr1i3tm1.1Arte Ahrtm1.2Arte Nr1i2tm3Arte • • • • • • • • • • - • • • • • • • • • • • • • • • • • • • • • • 12 8 17 17 11 18 18 B6.SJL(129S6)-Ptprca/BoyCrTac- Rag2tm1Fwa N10 129S6/SvEvTac-Rag2tm1Fwa C.129S6(B6)-Rag2tm1Fwa N12 B6.129S6-Rag2tm1Fwa N12 B6.129S6-Rag2tm1Fwa Tg(TcraTcrb)1100Mjb B6.129S6-Rag2tm1Fwa Tg(TcraTcrb)425Cbn CByB6F1-Tg(HRAS)2Jic C.B-Igh1b Prkdcscid Lystbg/GbmsTac SJL/JCrNTac NTac:SHR NTac:SD 129S6/SvEv-Stat1tm1Rds NTac:NIHS-Foxn1nu Tac:SW STOCK Tg(Prnp-MAPT*P301L)JNPL3Hlmc STOCK Tg(Prnp-MAPT*P301L)JNPL3Hlmc B6.Cg(SJL)-Tg(TNF) N21+? B6.129-Trp53tm1Brd N12 B6;129-Trp53tm1Brd N4 B6;129-Trp53tm1Brd N5 HanTac:WH HanTac:WKY • • • 3
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