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Mendelovo Centrum pro vzdělání v biologii, biomedicíně a bioinformatice
a
Centrum molekulární biologie a genové terapie FN
zvou na přednášku
TOPOGRAPHY OF GENES AND CHROMOSOME TERRITORIES
INVOLVED IN EWING SARCOMA SPECIFIC TRANSLOCATION
29. listopadu 2010, v 14:30 hodin
posluchárna Centra molekulární biologie a genové terapie IHOK FN Brno
(pracoviště Dětská nemocnice, Černopolní 9, 613 00 Brno)
Mgr. Renata Taslerová, Ph.D.
(CMBGT, IHOK, FN Brno)
Abstract: Ewing sarcoma is a primary malignant high aggressive tumor arising in the medullar cavity
of bones. The malignity exhibits a specific karyotypic abnormality, reciprocal translocation between
the EWSR1 gene and one of five possible fusion partners (FLI1, ERG, ETV1, E1A and FEV). However,
the translocation t(11,22)(q24,q12) between the EWSR1 and FLI1 genes is most common, it occurs in
more than 85% of Ewing sarcomas. Several studies have shown that the fusion genes as well as the
whole derivative chromosomes change their positions after the translocation event in interphase
nuclei of Ewing sarcoma and other malignities. The most recent data strongly suggest that nuclear
chromatin organization has a substantial influence on the regulation of gene expression.
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